ONCOLOGY SECTION

The cytogenetic oncology section is divided into four disease specific teams:

i. Leukaemia's / Pre-leukaemia's
ii. Stem Cell Transplantation
iii. Solid Tumours
iv. Lymphoproliferative Diseases

The section processed around 7000 haematological blood, marrow and paediatric solid tumour samples in 2008. Around 50% of these are diagnostic cases, with the remainder being referred for a wide range of follow up studies. A combination of G-banded karyotyping, Fluorescence In-Situ Hybridisation (FISH) and molecular genetic testing techniques are employed. The results obtained assist in the diagnosis and classification of leukaemias, solid tumours, and related disorders, provide prognostic information for use in risk stratification, and enable assessment of disease status post treatment/transplantation.

For further details of sample requirements and reporting times click here.

For information about the Central England Haemato-Oncology Research Biobank please click here

Downloads:

Referral Forms

Cytogenetics referral form

Molecular genetics referral form

Service Update Letters

CML Service update letter February 2011

Haematology Service update letter December 2009

CML Service update letter October 2007

Other Downloads

Imatinib trough plasma levels study: third annual report

Definitions used in molecular and cytogenetic CML reports

Guidelines for Mutation Analysis of BCR/ABL Kinase Domain (AKD analysis)

Audit into the frequency and nature of monitoring in CML patients 2007

Imatinib trough plasma levels study protocol

a)	b)
Ilustrations of BCR/ABL gene rearrangements
a) G banded chromosomes with a t(9;22)(q34;q11.2) rearrangement	b) FISH image showing BCR/ABL gene rearrangements

Author: Joanne Mason Authorised by: Sally Jeffries Version 1.0.6.6
Authorised on 02/12/2011 Next review date 02/12/2013
ONLY VALID ON DAY OF PRINTING